ZRANB3蛋白抗体
规格：1mg/1ml
英文名： ZRANB3
别名： 4933425L19Rik; MGC105033; MGC75012; OTTHUMP00000197449; Zinc finger Ran-binding domain-containing protein 3; Zinc finger, RAN- binding domain containing 3; ZRAB3_HUMAN; Zranb3.
分子量： 123kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZRANB3
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞核
ZRANB3蛋白抗体产品介绍：background: Zinc finger Ran-binding domain-containing protein 3 (ZRANB3) is a 1079 amino acid gene product that belongs to the SNF2/RAD54 helicase family. Other family members are known to be involved in DNA repair and mitotic recombination. This family of proteins often plays an active role in recombination processes in cooperation with other members of the RAD52 epistasis group. The ZRANB3 product contains one helicase ATP-binding domain, one helicase C-terminal domain and one RanBP2-type zinc finger. RanBP2-type zinc fingers mediate the helicase binding to RNA. Similar to other Ran-binding zinc finger proteins, ZRANB3 likely acts as a splice factor for alternative splicing events of pre-mRNA transcripts. ZRANB proteins may also interfere with constitutive 5'-splice site selection. Function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as aZRANB3蛋白抗体 structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. Subunit: Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin). Subcellular Location: Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. Similarity: BelongsZRANB3蛋白抗体 to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 RanBP2-type zinc finger. Gene ID: 84083 Database links: Entrez Gene: 84083 Human SwissProt: Q5FWF4 Human Unigene: 658422 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ZRANB3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid