毛皮质细胞角蛋白/细胞角蛋白40抗体
规格：1mg/1ml
英文名： hair cortex Cytokeratin
别名： CK-40; Cytokeratin-40; Cytokeratin40; K1C40_HUMAN; Cytokeratin 40; Keratin, type I cytoskeletal 40; Keratin-40; KRT40; Type I hair keratin Ka36.
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human hair cor
交叉反应：Human, Mouse, Dog, Cow, Horse, Sheep,
细胞定位：
毛皮质细胞角蛋白/细胞角蛋白40抗体产品介绍：background: Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome毛皮质细胞角蛋白/细胞角蛋白40抗体. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes. Function: The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the毛皮质细胞角蛋白/细胞角蛋白40抗体 type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. Subunit: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level). Similarity: Belongs to the intermediate filament family. Database links: SwissProt: Q6A162 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
毛皮质细胞角蛋白/细胞角蛋白40抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid