H2A组蛋白家族成员J抗体
规格：1mg/1ml
英文名： H2AFJ
别名： H2A histone family member E; H2A histone family member J; H2A/E; H2a/j; H2AFE; H2AFJ; H2AJ; H2AJ_HUMAN; HISHistone gene clusater 1 H2AJ; HIST1 Cluster H2AJ; HIST1H2AJ; Histone H2A.J.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human H2AFJ
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞核
H2A组蛋白家族成员J抗体产品介绍：background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. [provided by RefSeq, Jul 2008] Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the H2A组蛋白家族成员J抗体cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Subcellular Location: Nucleus. Chromosome. Post-translational modifications: Monoubiquitination of H2A组蛋白家族成员J抗体Lys-120 gives a specific tag for epigenetic transcriptional repression. Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription. Similarity: Belongs to the histone H2A family. Gene ID: 55766 Database links: Entrez Gene: 55766 Human Omim: 602791 Human SwissProt: Q9BTM1 Human Unigene: 524280 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
H2A组蛋白家族成员J抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid