鸟苷酸环化酶/GCS-β-2/GCS-β2抗体
规格：1mg/1ml
英文名： Guanylate Cyclase
别名： GC SB2; GCS BETA 2; GTP pyrophosphate lyase; Guanylate cyclase 1 soluble beta 2; GCYA2_HUMAN; Guanylate cyclase soluble beta 2; Guanylate cyclase soluble beta 2 chain; Guanylate cyclase soluble subuni
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Guanylat
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞浆
鸟苷酸环化酶/GCS-β-2/GCS-β2抗体产品介绍：background: Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one ?subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both 鸟苷酸环化酶/GCS-β-2/GCS-β2抗体display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver Function: Guanylate Cyclase is an heterodimer of an alpha and a beta chain. Its enzymatic activity transforms GTP to GMP releasing a diphosphate. It binds 1 or 2 hemes per heterodimer. It is activated by nitric oxide in the presence of magnesium or manganese ions. There are two types of guanylate cyclase: soluble form and membrane-associated receptor form. Subunit: 鸟苷酸环化酶/GCS-β-2/GCS-β2抗体Heterodimer of an alpha and a beta chain. Subcellular Location: Cytoplasmic. Tissue Specificity: Isoform 1 is expressed in fetal brain, liver, colon, endothelium and testis. Isoform 2 is expressed only in liver, colon and endothelium. Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Gene ID: 2974 Database links: Entrez Gene: 2974 Human Entrez Gene: 239134 Mouse Entrez Gene: 25206 Rat Omim: 603695 Human SwissProt: O75343 Human SwissProt: Q6XE41 Mouse SwissProt: P22717 Rat Unigene: 411573 Human Unigene: 10933 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟苷酸环化酶/GCS-β-2/GCS-β2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid