通用转录因子3C多肽5/TFIIIC90抗体
规格：1mg/1ml
英文名： GTF3C5
别名： FLJ20857; General transcription factor 3C polypeptide 5; General transcription factor IIIC polypeptide 5 63kDa; GTF3C5; TF3C epsilon; TF3C-epsilon; TF3C5_HUMAN; TFIIIC 63 kDa subunit; TFiiiC2 63; TFII
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GTF3C5
交叉反应：Human,
细胞定位：细胞核
通用转录因子3C多肽5/TFIIIC90抗体产品介绍：background: RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB 通用转录因子3C多肽5/TFIIIC90抗体complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB. Function: Involved in RNA polymerase III-mediated transcription. Integral, tightly 通用转录因子3C多肽5/TFIIIC90抗体associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. Subcellular Location: Nucleus. Similarity: Belongs to the TFIIIC subunit 5 family. Gene ID: 9328 Database links: Entrez Gene: 9328 Human Entrez Gene: 417164 Chicken Entrez Gene: 464820 Chimpanzee Entrez Gene: 101143035 Gorilla Entrez Gene: 70239 Mouse Omim: 604890 Human SwissProt: Q5T7U2 Human SwissProt: Q5T7U3 Human SwissProt: Q9Y5Q8 Human SwissProt: Q8R2T8 Mouse Unigene: 495417 Human Unigene: 274120 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
通用转录因子3C多肽5/TFIIIC90抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid