髓鞘相关糖蛋白CD57抗体
规格：1mg/1ml
英文名： CD57
别名： 3-glucuronyltransferase 1; 3-glucuronyltransferase; B3GA1_HUMAN; B3GAT1; Beta 1 3 glucuronyltransferase 1; Beta-1; CD 57; CD57; CD57 antigen; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltran
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD57
交叉反应：Human, Mouse, Rat, Chicken,
细胞定位：细胞浆 细胞膜
髓鞘相关糖蛋白CD57抗体产品介绍：background: CD57 recognizes a (Mr 100-110kDa) oligosaccharide antigenic determinant on myeloid cells and on a variety of polypeptides, lipids and chondroitan sulfate proteoglycans. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system. Function: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most 髓鞘相关糖蛋白CD57抗体effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. Subunit: 髓鞘相关糖蛋白CD57抗体Homodimer (Potential). Subcellular Location: Golgi apparatus membrane; Single-pass type II membrane protein. Tissue Specificity: Mainly expressed in the brain. Similarity: Belongs to the glycosyltransferase 43 family. Gene ID: 27087 Database links: Entrez Gene: 27087 Human Omim: 151290 Human SwissProt: Q9P2W7 Human Unigene: 381050 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD57是一种分子量为110KD的糖蛋白,它是自然杀伤细胞(NK)和杀伤细胞的特异性表面抗原。CD57表达于15-20%的外周血单核细胞，60%的NK活化细胞以及T细胞亚群。该抗体可以标记NK细胞，也可识别非**组织的一些细胞。可用于NK细胞介导的细胞毒、NK细胞及T细胞亚群的功能等方面的研究，也可标记神经***细胞及其肿瘤。
髓鞘相关糖蛋白CD57抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid