通用转录因子2H亚基2/TFIIH p44抗体
规格：1mg/1ml
英文名： GTF2H2
别名： Basic transcription factor 2 44 kDa subunit; BTF2; BTF2 p44; BTF2-p44; BTF2P44; General transcription factor IIH; General transcription factor IIH polypeptide 2; General transcription factor IIH subun
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GTF2H2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
通用转录因子2H亚基2/TFIIH p44抗体产品介绍：background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been通用转录因子2H亚基2/TFIIH p44抗体 described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008] Function: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Subunit: One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to通用转录因子2H亚基2/TFIIH p44抗体 form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3. Interacts with varicella-zoster virus IE63 protein. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed, with higher expression in skeletal muscle. Similarity: Belongs to the GTF2H2 family. Contains 1 VWFA domain. Gene ID: 2966 Database links: Entrez Gene: 2966 Human Entrez Gene: 511829 Cow Entrez Gene: 23894 Mouse Entrez Gene: 294693 Rat Omim: 601748 Human SwissProt: Q2TBV5 Cow SwissProt: Q13888 Human SwissProt: Q9JIB4 Mouse SwissProt: A0JN27 Rat Unigene: 191356 Human Unigene: 607501 Human Unigene: 272533 Mouse Unigene: 144260 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
通用转录因子2H亚基2/TFIIH p44抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid