G蛋白偶联受体激酶4抗体
规格：1mg/1ml
英文名： GRK4
别名： G protein coupled receptor kinase 4; G protein-coupled receptor kinase 2 (Drosophila)-like; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; G proteinm coupled receptor kin
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRK4
交叉反应：Human, Mouse, Rat, Chicken,
细胞定位：细胞浆
G蛋白偶联受体激酶4抗体产品介绍：background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Subcellular Location:G蛋白偶联受体激酶4抗体 Cytoplasm. Cytoplasm; cell cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where co-localization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. Tissue Specificity: Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. Post-translational modifications: Palmitoylated. Similarity: Belongs to the protein kinase superfamily.G蛋白偶联受体激酶4抗体 AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. Gene ID: 2868 Database links: Entrez Gene: 2868 Human Entrez Gene: 14772 Mouse Entrez Gene: 59077 Rat Omim: 137026 Human SwissProt: P32298 Human SwissProt: O70291 Mouse SwissProt: P70507 Rat Unigene: 32959 Human Unigene: 117076 Mouse Unigene: 54517 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体激酶4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid