腺苷三磷酸结合盒转运体A1抗体
规格：1mg/1ml
英文名： ABCA1
别名： ABC1; ATP binding cassette transporter A1; ABC 1; ABC Transporter 1; ABCA 1; ABCA1; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1;
分子量： 254kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ABCA1
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞膜
腺苷三磷酸结合盒转运体A1抗体产品介绍：background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. Function: cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport. Subunit: Interacts with MEGF10. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in ***** tissues. Highest levels are found in pregnant uterus and uterus. Post-translational modifications: Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization. DISEASE: Defects in ABCA1 are a cause of high density腺苷三磷酸结合盒转运体A1抗体 lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature 腺苷三磷酸结合盒转运体A1抗体coronary artery disease (CAD) and a reduction in cellular cholesterol efflux. Similarity: Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Gene ID: 19 Database links: Entrez Gene: 19 Human Entrez Gene: 11303 Mouse Entrez Gene: 313210 Rat Omim: 600046 Human SwissProt: O95477 Human SwissProt: P41233 Mouse Unigene: 429294 Human Unigene: 277376 Mouse Unigene: 148916 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ABCA1是一种调节细胞内胆固醇流出的膜蛋白，其功能障碍将导致巨噬细胞内沉积大量的胆固醇而成为泡沫细胞，继而浸润血管壁，促进动脉粥样硬化的发生、发展。
腺苷三磷酸结合盒转运体A1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 转录调节因子 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid