**中心激酶MAP4K2抗体
规格：1mg/1ml
英文名： Germinal Center Kinase
别名： GC kinase; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; GC kinase; GCK; Germinal center kinase; germinal centre kinase (GC kinase); M4K2_HUMAN; MAP
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Germinal
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞浆
**中心激酶MAP4K2抗体产品介绍：background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008] Function: Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1**中心激酶MAP4K2抗体 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion. Subcellular Location: Cytoplasm. Basolateral cell membrane. Golgi apparatus membrane. Tissue Specificity: Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. Similarity: Belongs to the protein **中心激酶MAP4K2抗体kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain. Gene ID: 5871 Database links: Entrez Gene: 5871 Human Entrez Gene: 26412 Mouse Omim: 603166 Human SwissProt: Q12851 Human SwissProt: Q61161 Mouse Unigene: 534341 Human Unigene: 25860 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产**中心激酶MAP4K2抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 **细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit