FSTL3/FLRG蛋白抗体
规格：1mg/1ml
英文名： FSTL3
别名： FLRG; follistatin-like 3; follistatin-like 3 glycoprotein; Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3; FSRP; Fstl3; FSTL3_HUMAN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FSTL3
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞核 细胞浆
FSTL3/FLRG蛋白抗体产品介绍：background: FLRG (follistatin-related gene, follistatin-like-3 or FSTL3) is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differen-tiation factors and regulate their activity during development. The FSTL3 protein contains 2 potential N-glycosylation sites and the predicted mass of the unmodified core protein is 27 kDa. FLRG is expressed in a wide range of human and murine ***** tissues and its expression seems to be tightly regulated during murine embryogenesis. Immunohistochemistry reveals the presence of FLRG in the basement membrane between the dermis and the epidermis and around blood vessels. Function: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; moreFSTL3/FLRG蛋白抗体 effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation FSTL3/FLRG蛋白抗体via interaction with MLLT10. Subcellular Location: Secreted and Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. Tissue Specificity: Expressed in a wide range of tissues. DISEASE: Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. Similarity: Contains 2 follistatin-like domains. Contains 2 Kazal-like domains. Contains 1 TB (TGF-beta binding) domain. Gene ID: 10272 Database links: Entrez Gene: 10272 Human SwissProt: O95633 Human Unigene: 529038 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FSTL3/FLRG蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 干细胞 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid