13号染色体开放阅读框14抗体
规格：1mg/1ml
英文名： FRY/C13orf14
别名： C13orf14; FRY_HUMAN; Protein furry homolog.
分子量： 339kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FRY/C13o
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
细胞定位：
13号染色体开放阅读框14抗体产品介绍：background: In yeast, flies, and worms, the Dbf2-related (Ndr) kinase protein family functions in various aspects of cell polarity and morphogenesis. The Drosophila melanogaster protein, furry, is responsible for maintaining integrity of polarized cell extensions, such as epidermal hair cells, lateral extensions of the arista and the shafts of neuronal sensory bristles. Mutations in furry lead to the formation of branched arista laterals, bristles and hairs. The yeast homolog of furry, Mor2, is important for the localization of F-actin specifically at the cell ends and is required for the restriction of the growth zones. The mammalian homolog of the Drosophila furry protein is FRY, also known as C13orf14, a 3,013 amino acid protein that probably functions as a transcription factor for genes that regulate the actin cytoskeleton. 13号染色体开放阅读框14抗体The gene encoding FRY maps to chromosome 13, which comprises nearly 4% of human DNA and contains around 114 million base pairs and 400 genes. Function: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. Subunit: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, 13号染色体开放阅读框14抗体to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Post-translational modifications: Phosphorylated by AURKA, CDK1 and PLK1. Similarity: Belongs to the furry protein family. Gene ID: 10129 Database links: Entrez Gene: 10129 Human Omim: 614818 Human SwissProt: Q5TBA9 Human Unigene: 507669 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
13号染色体开放阅读框14抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子 细胞骨架 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid