FKLF蛋白抗体
规格：1mg/1ml
英文名： FKLF
别名： 9830142A17; D12Ertd427e; FKLF; FKLF1; KLF11; KLF11_HUMAN; Krueppel like factor 11; Krueppel-like factor 11; MODY7; Tcfcp2l2; TGFB Early Growth Response 2; TGFB-inducible early growth response protein
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FKLF
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核
FKLF蛋白抗体产品介绍：background: The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] Function: Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Higher expression in erythroid cells.FKLF蛋白抗体 DISEASE: Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early *****hood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Similarity: Belongs to the Sp1 C2H2-type FKLF蛋白抗体zinc-finger protein family. Contains 3 C2H2-type zinc fingers. Gene ID: 8462 Database links: Entrez Gene: 8462 Human Entrez Gene: 194655 Mouse Entrez Gene: 313994 Rat Omim: 603301 Human SwissProt: O14901 Human SwissProt: Q8K1S5 Mouse Unigene: 12229 Human Unigene: 694968 Human Unigene: 9616 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FKLF蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 转录调节因子 糖尿病 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid