FGD5蛋白抗体
规格：1mg/1ml
英文名： FGD5
别名： FYVE, RhoGEF and PH domain containing protein 5; ZFYVE23; FGD5_HUMAN; Zinc finger FYVE domain containing protein 23.
分子量： 160kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FGD5
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞浆
FGD5蛋白抗体产品介绍：background: FGD5 is a 1,462 amino acid cytosolic protein that contains a DH domain, a FYVE-type zinc finger and two PH domains. FGD family members encode guanine nucleotide exchange factors that specifically activate the Rho GTPase Cdc42. All FGD proteins contain equivalent signaling domains and a conserved structural organization, which strongly suggests that these signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins. These proteins also control essential signals required during embryonic development. Function: FGD5 may activate CDC42, a member of the Ras like family of Rho and Rac proteins, by exchanging bound GDP forFGD5蛋白抗体 free GTP. It may also play a role in regulating the actin cytoskeleton and cell shape. FGD5 contains one DH (DBL-homology) domain one FYVE type zinc finger and two PH domains. There are two isoforms. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5. Tissue Specificity: Expressed in endothelial cells (at protein level). FGD5蛋白抗体Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. Gene ID: 152273 Database links: Entrez Gene: 152273 Human Entrez Gene: 232237 Mouse Entrez Gene: 362402 Rat Omim: 614788 Human SwissProt: Q6ZNL6 Human SwissProt: Q80UZ0 Mouse Unigene: 412406 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FGD5蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid