G蛋白偶联受体42抗体
规格：1mg/1ml
英文名： FFAR3/GPR42
别名： FFA3R; Ffar3; FFAR3_HUMAN; Free fatty acid receptor 3; G protein coupled receptor 41; G-protein coupled receptor 41; gpcr41; GPR41; gpr42.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FFAR3
交叉反应：Human,
细胞定位：细胞膜
G蛋白偶联受体42抗体产品介绍：background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPRs translate extracellular signals into intracellular signals (a process called G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR41 (G-protein coupled receptor 41), also known as FFAR3 (Free fatty acid receptor 3), is a 346 amino acid multi-pass membrane protein that belongs to the G protein-coupled receptor family. Expressed at high levels in adipose tissue and at lower levels throughout the body, GPR41 functions as a receptor for short chain fatty acids via elevation of intracellular calcium levels and inhibition ofG蛋白偶联受体42抗体 adenylyl cyclase. Function: Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate. Subcellular Location: Cell membrane. Tissue Specificity: Highest level in adipose tissue, and lower expression across all tissues tested. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 2865 Database links: Entrez Gene: 2865 Human Omim: 603821 HumanG蛋白偶联受体42抗体 SwissProt: O14843 Human Unigene: 248055 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体42抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 结合蛋白 G蛋白偶联受体 细胞骨架 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid