FCRL6蛋白抗体
规格：1mg/1ml
英文名： FCRL6
别名： Fc receptor homolog 6; Fc receptor-like 6; Fc receptor-like protein 6; Fc receptor-like protein 7; FcR-like protein 6; FcRH6; FcRL6; Fcrl6; FCRL6_HUMAN; FLJ16056; IFGP6; IgSF type I transmembrane rece
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FCRL6
交叉反应：Human,
细胞定位：细胞膜
FCRL6蛋白抗体产品介绍：background: The Fc receptor homolog (FcRH) family of proteins are related to the classical Fc receptors (FcR) and belong to the immunoglobulin receptor superfamily. The proteins in the FcRH family are type I transmembrane glycoproteins and consist of FcRH1-FcRH6. The genes encoding the human FcRH proteins map to chromosome 1, near the related FCR genes. The FcRH proteins, which are involved in immune system regulation, have immunoreceptor-tyrosine inhibitory motifs in their cytoplasmic domains. Mutations in the gene encoding for the FcRH proteins may be associated with systemic lupus erythematosus, autoimmune thyroid disease and rheumatoid arthritis. FCRL6蛋白抗体The FcRH genes are expressed primarily, although not exclusively, by mature B lineage cells, and may serve important regulatory roles in normal and neoplastic B cell development. Subunit: Interacts with PTPN11. Subcellular Location: Membrane. Tissue Specificity: Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected FCRL6蛋白抗体individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells. Post-translational modifications: Phosphorylated on Tyr residue, inducing association with PTPN11. Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 343413 Database links: Entrez Gene: 343413 Human Omim: 613562 Human SwissProt: Q6DN72 Human Unigene: 196955 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FCRL6蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid