甘露聚糖结合凝集素抗体
规格：1mg/1ml
英文名： Mannan Binding Lectin
别名： Mbl2; L-MBP; MBL; MBL-C; MBP-C; COLEC 1; COLEC1; HSMBPC; Mannan binding protein; Mannose binding lectin (protein C) 2 soluble; Mannose binding lectin 2 soluble; Mannose binding lectin; Mannose binding
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MBL
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：分泌型蛋白
甘露聚糖结合凝集素抗体产品介绍：background: This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]. 甘露聚糖结合凝集素抗体Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Subunit: Oligomeric complex of 3 or more homotrimers.甘露聚糖结合凝集素抗体 Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity. Subcellular Location: Secreted. Tissue Specificity: Plasma protein produced mainly in the liver. Similarity: Contains 1 C-type lectin domain. Contains 1 collagen-like domain. Gene ID: 4153 Database links: Entrez Gene: 4153 Human Entrez Gene: 17195 Mouse Omim: 154545 Human SwissProt: P11226 Human SwissProt: P41317 Mouse Unigene: 499674 Human Unigene: 30045 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MBL （mannan binding lectin）甘露聚糖结合凝集素，MBL是一种兼有调理素和直接激活补体功能的**分子，参与构成抗感染的**道防线。MBL2在发生急性期反应时由肝脏分泌，并参与天然**防御。凝集素配体可以存在于各种各样的微生物中，两者结合后可以导致调理作用并激活补体系统。
甘露聚糖结合凝集素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid