核糖核苷酸还原酶1抗体
规格：1mg/1ml
英文名： RRM1
别名： ribonucleotide reductase R1 mRNA; R1; Ribonucleoside diphosphate reductase large subunit ; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleotid
分子量： 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRM1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
产品介绍：background: RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate 核糖核苷酸还原酶1抗体reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment. Function: Provides the precursors necessary for DNA synthesis. Catalyzes the 核糖核苷酸还原酶1抗体biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Subunit: Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Subcellular Location: Cytoplasm. Similarity: Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone核糖核苷酸还原酶1抗体 domain. Gene ID: 6240 Database links: Entrez Gene: 6240 Human Entrez Gene: 20133 Mouse Entrez Gene: 685579 Rat Omim: 180410 Human SwissProt: P23921 Human SwissProt: P07742 Mouse Unigene: 445705 Human Unigene: 197486 Mouse Unigene: 162454 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 核糖核苷酸还原酶普遍存在于很多生物中,是生物体内**的催化4种核糖核苷酸还原并核糖核苷酸还原酶1抗体生成相应的脱氧核糖核苷酸的酶. 核糖核苷酸还原酶1也是DNA合成和修复的关键酶和限速酶,对细胞的增殖和分化起着调控作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid