p53正向细胞凋亡调控因子抗体
规格：1mg/1ml
英文名： BBC3/PUMA
别名： PUMA; bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA al
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BBC3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞浆 线粒体
p53正向细胞凋亡调控因子抗体产品介绍：background: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] Function: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. p53正向细胞凋亡调控因子抗体Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Essential for ER stress-induced cell death. Subunit: Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1. Subcellular Location: Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. Similarity: Belongs to the Bcl-2 family. Gene ID: 27113 Database links: Entrez Gene: 27113 Human Entrez Gene: 170770 Mouse Entrez Gene: 317673 Rat Omim: 605854 Human SwissProt: Q9BXH1 Human SwissProt: Q99ML1 Mouse SwissProt:p53正向细胞凋亡调控因子抗体 Q80ZG6 Rat Unigene: 467020 Human Unigene: 7660 Mouse Unigene: 25176 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PUMA在由p53诱导而经历细胞凋亡的细胞中被p53活化。在线粒体，PUMA 诱导细胞色素C的释放和激活对细胞凋亡的快速诱导。PUMA 与Bcl2、Bcl-XL、类Bcl2-1蛋白相互作用，促使线粒体易位和BAX的多聚化。PUMA在通过依赖细胞色素C/APAF1 途径介导p53诱导的细胞死亡中也发挥作用。
p53正向细胞凋亡调控因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid