络丝蛋白抗体
规格：1mg/1ml
英文名： Reelin
别名： Reelin; Reeler; RELN; RL; LIS2; PRO1598; RELN_HUMAN.
分子量： 400-450;300;180-kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RELN
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Guinea Pig,
细胞定位：分泌型蛋白
络丝蛋白抗体产品介绍：background: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF. Function: This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia络丝蛋白抗体, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. Subcellular Location: Secreted Tissue Specificity: High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). Post-translational 络丝蛋白抗体modifications: N-glycosylated; more than 90% of the glycans are sialylated. Similarity: Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains. Gene ID: 5649 Database links: Entrez Gene: 5649 Human Entrez Gene: 19699 Mouse Entrez Gene: 24718 Rat Omim: 600514 Human SwissProt: P78509 Human SwissProt: Q60841 Mouse SwissProt: P58751 Rat Unigene: 655654 Human Unigene: 425236 Mouse Unigene: 98353 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Reelin蛋白作用目前还在进一步研究中，但有学者认为它与β-Amyloid 的神经缠结有相对应的作用。
络丝蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid