**球蛋白lambda样肽1抗体
规格：1mg/1ml
英文名： IGLL1
别名： 14.1; AGM2; CD179 antigen-like family member B; CD179B; CD179b antigen; Ig lambda 5; Ig lambda-5; IGL1; IGL5; IGLJ14.1; IGLL; Igll1; IGLL1_HUMAN; IGO; IGVPB; Immunoglobulin lambda like polypeptide 1 p
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGLL1
交叉反应：Human,
细胞定位：
**球蛋白lambda样肽1抗体产品介绍：background: The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants **球蛋白lambda样肽1抗体encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Critical for B-cell development. Subunit: Associates non-covalently with VPREB1. Subcellular Location: Secreted. Tissue Specificity: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative). DISEASE: Agammaglobulinemia 2 (AGM2) [MIM:613500]: A primary immunodeficiency **球蛋白lambda样肽1抗体characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Database links: UniProtKB/Swiss-Prot: P15814.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
**球蛋白lambda样肽1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid