细胞纤毛内转运同源蛋白140抗体
规格：1mg/1ml
英文名： IFT140
别名： Gs114; Intraflagellar transport 140 homolog (Chlamydomonas); WD and tetratricopeptide repeats protein 2; IF140_HUMAN; WDTC2.
分子量： 165kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IFT140
交叉反应：Human, Mouse, Rat, Chicken, Dog, Horse,
细胞定位：
细胞纤毛内转运同源蛋白140抗体产品介绍：background: IFT140 is a gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. Subunit: Component of the IFT complex A (IFT-A). Subcellular Location: Cytoplasm, 细胞纤毛内转运同源蛋白140抗体cytoskeleton, cilium basal body. DISEASE: Mainzer-Saldino syndrome (MZSDS) [MIM:266920]: A rare autosomal recessive disease characterized by phalangeal cone-shaped epiphyses, chronic renal disease, nearly constant retinal dystrophy, and mild细胞纤毛内转运同源蛋白140抗体 radiographic abnormality of the proximal femur. Occasional features include short stature, cerebellar ataxia, and hepatic fibrosis. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 9 TPR repeats. Contains 5 WD repeats. Gene ID: 9742 Database links: Entrez Gene: 9742 Human Entrez Gene: 106633 Mouse SwissProt: Q96RY7 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞纤毛内转运同源蛋白140抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid