Bruton酪氨酸激酶抑制剂蛋白抗体
规格：1mg/1ml
英文名： IBTK
别名： BTKI; IBtk; IBTK_HUMAN; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase.
分子量： 150kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IBTK
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：
Bruton酪氨酸激酶抑制剂蛋白抗体产品介绍：background: IBTK is a encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Subunit: Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK. Subcellular Location: Cytoplasm. Membrane;Bruton酪氨酸激酶抑制剂蛋白抗体 Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation. Isoform 2: Nucleus. Tissue Specificity: Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, Bruton酪氨酸激酶抑制剂蛋白抗体thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. Similarity: Contains 3 ANK repeats. Contains 2 BTB (POZ) domains. Contains 3 RCC1 repeats. Database links: UniProtKB/Swiss-Prot: Q9P2D0.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Bruton酪氨酸激酶抑制剂蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid