干扰素诱导跨膜蛋白5抗体
规格：1mg/1ml
英文名： IFITM5
别名： Bone-restricted interferon-induced transmembrane protein-like protein; BRIL; Fragilis4; Hrmp1; IFITM5; IFM5_HUMAN; Interferon-induced transmembrane protein 5.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IFITM5
交叉反应：Human,
细胞定位：
干扰素诱导跨膜蛋白5抗体产品介绍：background: IFITM5 is a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). Function: Plays a role in bone mineralization (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein (By similarity). DISEASE: Osteogenesis imperfecta 5 (OI5) [MIM:610967]: 干扰素诱导跨膜蛋白5抗体An autosomal dominant form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, 干扰素诱导跨膜蛋白5抗体and blue sclerae. OI5 patients manifest moderate to severe bone fragility, calcification of the forearm interosseous membrane, radial head dislocation, a subphyseal metaphyseal radiodense line, and hyperplastic callus formation. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the CD225/Dispanin family. Database links: UniProtKB/Swiss-Prot: A6NNB3.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素诱导跨膜蛋白5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid