白细胞酪氨酸激酶受体抗体
规格：1mg/1ml
英文名： LTK
别名： ALK; Anaplastic lymphoma kinase; Leukocyte receptor tyrosine kinase; Leukocyte tyrosine kinase; Leukocyte tyrosine kinase receptor; Leukocyte tyrosine kinase receptor; Ltk; LTK_HUMAN; Protein tyrosine
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LTK
交叉反应：Human, Mouse, Horse, Rabbit,
细胞定位：
白细胞酪氨酸激酶受体抗体产品介绍：background: LTK is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. Function: Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs)白细胞酪氨酸激酶受体抗体 and ER to Golgi transport. Subunit: Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in non-hematopoietic cell lines and T- and B-cell lines. DISEASE: Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B-cells and, therefore, to systemic lupus erythematosus (SLE).白细胞酪氨酸激酶受体抗体 SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 protein kinase domain. Database links: UniProtKB/Swiss-Prot: P29376.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞酪氨酸激酶受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 生长因子和** 激酶和磷酸酶 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid