缺氧诱导基因2蛋白抗体
规格：1mg/1ml
英文名： HIG2
别名： C7orf68; chromosome 7 open reading frame 68; HIG 2; HIG2; HLPDA_HUMAN; Hypoxia-inducible gene 2 protein; Hypoxia-inducible lipid droplet-associated protein; Hypoxia-inducible protein 2.
分子量： 7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIG2
交叉反应：Human,
细胞定位：细胞膜
缺氧诱导基因2蛋白抗体产品介绍：background: HIG2 is a 63 amino acid single-pass membrane protein that can be hypoxia induced by glucose deprivation. Expression of HIG2 is increased in cervical cancer cells but inhibited in renal cell carcinoma. When bound to the extracellular domain of frizzled-10, HIG2 enhances oncogenic Wnt signaling and its own transcription, which suggests HIG2 may function as an autocrine growth factor. HIG2 may be a candidate for development of molecular-targeting therapy and could serve as a prominent diagnostic tumor marker for patients with renal carcinomas. The gene encoding HIG2 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, 缺氧诱导基因2蛋白抗体Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. Subcellular Location: Lipid droplet. Secreted. Membrane; Single-pass membrane protein (Potential). Tissue Specificity: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in 缺氧诱导基因2蛋白抗体fetal kidney with little or no expression observed in normal ***** heart, liver, lung, pancreas, prostate or spinal cord (at protein level). Database links: Entrez Gene: 29923 Human SwissProt: Q9Y5L2 Human Unigene: 706124 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
缺氧诱导基因2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 染色质和核信号 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid