人内源性逆转录病毒膜糖蛋白2抗体
规格：1mg/1ml
英文名： HERV-FRD
别名： EFRD1_HUMAN; Endogenous retrovirus group FRD member 1; Envelope polyprotein; ERVFRD-1; FLJ41944; FLJ90611; GLLL6191; HERV FRD 6p24.1 provirus ancestral Env polyprotein; HERV FRD; HERV FRD provirus anc
分子量： 21/37/58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HERV-FRD
交叉反应：Human,
细胞定位：
人内源性逆转录病毒膜糖蛋白2抗体产品介绍：background: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. SU mediates receptor recognition (By similarity). TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). Subunit: The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity). Subcellular Location: Virion. Transmembrane protein: Cell membrane; Single-pass membrane protein (Potential). 人内源性逆转录病毒膜糖蛋白2抗体Tissue Specificity: Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. Post-translational modifications: Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in 人内源性逆转录病毒膜糖蛋白2抗体order to allow membrane fusion (By similarity). Similarity: Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily. Database links: Entrez Gene: 2086 Human SwissProt: P60507 Human SwissProt: P60508 Human SwissProt: P61550 Human SwissProt: P61565 Human SwissProt: P61566 Human SwissProt: P61567 Human SwissProt: P61570 Human SwissProt: Q14264 Human SwissProt: Q69384 Human SwissProt: Q902F8 Human SwissProt: Q902F9 Human SwissProt: Q96L62 Human SwissProt: Q9N2J8 Human SwissProt: Q9N2J9 Human SwissProt: Q9N2K0 Human SwissProt: Q9NX77 Human SwissProt: Q9UKH3 Human SwissProt: Q9UQF0 Human Unigene: 250693 Human Unigene: 406976 Human Unigene: 631996 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人内源性逆转录病毒膜糖蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid