MMF诱导片段蛋白1抗体
规格：1mg/1ml
英文名： HERPUD1
别名： HERP; HERP1_HUMAN; HERPUD1; Homocysteine inducible endoplasmic reticulum stress inducible ubiquitin like domain member 1; Homocysteine responsive endoplasmic reticulum resident ubiquitin like domain m
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HERPUD1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
MMF诱导片段蛋白1抗体产品介绍：background: HERPUD1 is a includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. MMF诱导片段蛋白1抗体The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]. Function: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Subunit: Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Tissue MMF诱导片段蛋白1抗体Specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease. Similarity: Contains 1 ubiquitin-like domain. Database links: Entrez Gene: 9709 Human Entrez Gene: 64209 Mouse Entrez Gene: 85430 Rat Omim: 608070 Human SwissProt: Q15011 Human SwissProt: Q9JJK5 Mouse Unigene: 146393 Human Unigene: 29151 Mouse Unigene: 4028 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MMF诱导片段蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid