HERC4 E3泛素蛋白连接酶抗体
规格：1mg/1ml
英文名： HERC4
别名： DKFZP564G092; HECT and RLD domain containing E3 ubiquitin protein ligase 4; HECT domain and RCC1 like domain containing protein 4; HECT domain and RCC1-like domain-containing protein 4; Hect domain an
分子量： 119kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HERC4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
HERC4 E3泛素蛋白连接酶抗体产品介绍：background: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). Function: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the HERC4 E3泛素蛋白连接酶抗体spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). Subcellular Location: Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution. Tissue Specificity: Expressed in brain and testis and detected in heart and placenta.[DEVELOPMENTAL STAGE] ExpressedHERC4 E3泛素蛋白连接酶抗体 in fetal brain. Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 7 RCC1 repeats. Gene ID: 26091 Database links: Entrez Gene: 26091 Human Entrez Gene: 67345 Mouse Omim: 609248 Human SwissProt: Q5GLZ8 Human SwissProt: Q6PAV2 Mouse Unigene: 51891 Human Unigene: 234437 Mouse Unigene: 441725 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HERC4 E3泛素蛋白连接酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid