鸟苷酸释放因子p532蛋白抗体
规格：1mg/1ml
英文名： HERC1
别名： Guanine nucleotide exchange factor p532; Hect (homologous to the E6 AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1) like domain (RLD) 1; HECT and RLD domain containing E3 ubiquitin protein ligase
分子量： 532kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HERC1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：
鸟苷酸释放因子p532蛋白抗体产品介绍：background: HERC1 is a stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. Function: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Subunit: Interacts with TSC2; 鸟苷酸释放因子p532蛋白抗体interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A. Subcellular Location: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions. Tissue Specificity: Widely expressed. Similarity: Contains 1 B30.2/SPRY domain. Contains 1 HECT鸟苷酸释放因子p532蛋白抗体 (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 14 RCC1 repeats. Contains 11 WD repeats. Gene ID: 8925 Database links: Entrez Gene: 538029 Cow Entrez Gene: 8925 Human Entrez Gene: 235439 Mouse Entrez Gene: 100153537 Pig Entrez Gene: 315771 Rat Omim: 605109 Human SwissProt: Q15751 Human Unigene: 210385 Human Unigene: 244179 Mouse Unigene: 232088 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟苷酸释放因子p532蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid