人肿瘤抑制蛋白抗体
规格：1mg/1ml
英文名： HELZ
别名： DKFZp586G1924; Down regulated in human cancers; DRHC; Helicase with zinc finger; HUMORF 5; HUMORF5; KIAA0054; MGC163454; Probable helicase with zinc finger domain; HELZ_HUMAN.
分子量： 219kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HELZ
交叉反应：Human, Mouse, Rat,
细胞定位：
产品介绍：background: Helicases comprise a class of enzymes that function as motor proteins which move along nucleic acid phosphodiester bonds, 人肿瘤抑制蛋白抗体effectively separating two annealed nucleic acid strands. RNA helicases alter the conformation of RNA, specifically by unwinding double-stranded RNA regions to yield single RNA strands, a process which changes the biological activity of the RNA molecule. HELZ (helicase with zinc finger), also known as DHRC or HUMORF5, is a 1,942 amino acid nuclear protein that contains one C3H1-type zinc finger and belongs to the RNA helicase superfamily. Expressed ubiquitously during embryonic development, HELZ is thought to function as an RNA helicase that modifies RNA structure and plays a role in the development of multiple organs and tissues within the developing embryo. Function: May 人肿瘤抑制蛋白抗体act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo. Subunit: Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II.人肿瘤抑制蛋白抗体 Subcellular Location: Nucleus (Probable). Tissue Specificity: Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines. Similarity: Belongs to the DNA2/NAM7 helicase family. Contains 1 C3H1-type zinc finger. Database links: UniProtKB/Swiss-Prot: P42694.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人肿瘤抑制蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid