HEG同源蛋白1抗体
规格：1mg/1ml
英文名： HEG1
别名： HEG; HEG1; HEG1_HUMAN; KIAA1237; MST112; MSTP112; HEG homolog 1; Protein HEG homolog 1.
分子量： 144kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HEG1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
HEG同源蛋白1抗体产品介绍：background: HEG1 (HEG homolog 1) is also known as HEG and is a 1,381 amino acid protein that exists as two alternatively spliced isoforms, one of which is a single-pass membrane protein and the other of which is secreted. HEG1, which is expressed in endothelial cells and smooth muscle cells of heart tissue, contains two EGF-like domains that play a role in calcium-binding events which may regulate concentric heart growth. The gene encoding HEG1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3HEG同源蛋白1抗体 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. Function: Receptor component of the CCM signaling pathway which is a crucial regulatorHEG同源蛋白1抗体 of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. Subunit: Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction. Isoform 2: Secreted (Potential). Similarity: Contains 2 EGF-like domains. Gene ID: 57493 Database links: Entrez Gene: 57493 Human Omim: 614182 Human SwissProt: Q9ULI3 Human Unigene: 477420 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HEG同源蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid