E3连接酶抑制素受体抗体
规格：1mg/1ml
英文名： HECTD1
别名： E3 ligase for inhibin receptor; E3 ubiquitin protein ligase HECTD1; E3 ubiquitin-protein ligase HECTD1; EULIR; HECD1_HUMAN; HECT domain containing protein 1; HECT domain-containing protein 1; HECTD1;
分子量： 289kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HECTD1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：
E3连接酶抑制素受体抗体产品介绍：background: EULIR is a major component of the ubiquitin-proteasome system and plays a role in determining the specificity of ubiquitin conjugation. It is responsible for transferring ubiquitin to targeted substrates from an E2 ubiquitin-conjugating enzyme through the intermediate formation of a thiol ester with ubiquitin. Similar to a number of other E3 ubiquitin ligases, EULIR contains an N-terminal ankyrin repeat domain, a mind bomb (mib) domain and a C-terminal HECT (homologous to E6-AP C-terminus) domain. The HECT domain is responsible for the ubiquitin ligase activity, catalyzing polyubiquitination. EULIR is ubiquitously expressed throughout early development and isE3连接酶抑制素受体抗体 important for the complete and proper closure of the neural tube. Mutations in the gene encoding EULIR can result in neural tube defects. Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme E3连接酶抑制素受体抗体and neural tube closure (By similarity). Subunit: Interacts with IGSF1. Similarity: Belongs to the UPL family. K-HECT subfamily. Contains 4 ANK repeats. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 1 MIB/HERC2 domain. Database links: Entrez Gene: 25831 Human Entrez Gene: 207304 Mouse Entrez Gene: 362736 Rat SwissProt: Q9ULT8 Human SwissProt: Q69ZR2 Mouse Unigene: 708017 Human Unigene: 249391 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
E3连接酶抑制素受体抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 染色质和核信号 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid