透明质酸结合蛋白4抗体
规格：1mg/1ml
英文名： HABP4
别名： IHABP-4; IHABP4; Intracellular hyaluronan-binding protein 4; Ki-1/57 intracellular antigen; HABP4_HUMAN.
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HABP4
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核 细胞浆
透明质酸结合蛋白4抗体产品介绍：background: The intracellular hyaluronan-binding protein 4 is a cytoplasmic and nuclear protein that is phosphorylated on serine and threonine residues. HABP4 is expressed as a protein of 413 amino acids and is phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375. HABP4 interacts with hyaluron, the adaptor protein RACK1, the transcription factor MEF2C and the chromatin remodeling factor CHD3, suggesting that it may be involved in the regulation of transcription. However, its actual function has yet to be elucidated. HABP4 is highly expressed in brain, heart, and kidney and is moderately expressed in skeletal 透明质酸结合蛋白4抗体muscle. Also, HABP4 is expressed in a variety of tumor cell lines and in activated, but not resting, leukocytes. Function: May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription. Subunit: Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with p53/TP53. Subcellular Location: Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes. Tissue Specificity: Highly expressed in brain, heart, and kidney, and moderately透明质酸结合蛋白4抗体 expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes. Post-translational modifications: Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375 (Probable). Gene ID: 22927 Database links: Entrez Gene: 22927 Human SwissProt: Q5JVS0 Human Unigene: 494567 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
透明质酸结合蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid