G蛋白偶联受体MRGX2蛋白抗体
规格：1mg/1ml
英文名： GPCR MRGX2
别名： Mas-related G-protein coupled receptor member X2; MRGPRX2; MRGX2; MRGX2_HUMAN.
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPCR MRG
交叉反应：Human,
细胞定位：
G蛋白偶联受体MRGX2蛋白抗体产品介绍：background: Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function. Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation G蛋白偶联受体MRGX2蛋白抗体or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupledG蛋白偶联受体MRGX2蛋白抗体. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Database links: Entrez Gene: 117194 Human Omim: 607228 Human SwissProt: Q96LB1 Human Unigene: 350566 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体MRGX2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 G蛋白偶联受体 新陈代谢 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid