G蛋白偶联受体HM74蛋白抗体
规格：1mg/1ml
英文名： GPCR HM74
别名： G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; HCA3; HCAR3; HM74; HM74B; Hydroxycarboxylic acid receptor 3; Niacin receptor 2; NIACR2; Nic
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPCR HM7
交叉反应：Human,
细胞定位：
G蛋白偶联受体HM74蛋白抗体产品介绍：background: HM74 is a member of the G protein coupled receptor (GPCR) superfamily. In humans, HM74 is encoded by two different genes (GPR109A and GPR109B) that express two distinct proteins, namely HM74A and HM74B (also known as simply HM74), which are 96% homologous. In mice and rats, only one gene (deisngnated Gpr109a) encodes the HM74 protein. HM74B is a G(i) protein-coupled receptor that mediates the metabolic effects of nicotinic acid. Localizing to the cell membrane, HM74B is highly expressed in adipocytes, immune cells and spleen and, like all members of the GPCR superfamily, contains seven transmembrane domains. HM74B lacks the characteristic N-linked glycosylation sites that are present in other GPCR family members and also shows a more diverged amino acid sequenceG蛋白偶联受体HM74蛋白抗体 homology from most family members, implying different ligand specificity Function: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expression largelyG蛋白偶联受体HM74蛋白抗体 restricted to adipose tissue and spleen. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 8843 Database links: Entrez Gene: 8843 Human Omim: 606039 Human SwissProt: P49019 Human Unigene: 458425 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体HM74蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid