6号染色体开放阅读框173抗体
规格：1mg/1ml
英文名： C6ORF173
别名： cancer upregulated gene 2; Cancer-up-regulated gene 2 protein; CENP-W; cenpw; CENPW_HUMAN; Centromere protein W; chromosome 6 open reading frame 173; CUG2; hypothetical protein LOC387103.
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C6ORF173
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
6号染色体开放阅读框173抗体产品介绍：background: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA,6号染色体开放阅读框173抗体 and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. Subunit: Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of histone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA. Subcellular Location: Nucleus. Chromosome, centromere.6号染色体开放阅读框173抗体 Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. Tissue Specificity: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. Similarity: Belongs to the CENPW family. Database links: Entrez Gene: 387103 Human Omim: 611264 Human SwissProt: Q5EE01 Human Unigene: 486401 Human Important 6号染色体开放阅读框173抗体Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid