补体C3IP1抗体
规格：1mg/1ml
英文名： C3IP1
别名： C3IP1; CUL3 interacting protein 1; CUL3-interacting protein 1; DKIR; FLJ27152; Kelch like 12 (Drosophila); Kelch like 12; Kelch like 12 variant; Kelch like protein 12; kelch like protein C3IP1; Kelch-
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C3IP1
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
细胞定位：
补体C3IP1抗体产品介绍：background: KLHL12 is a 568 amino acid protein that is a component of an ubiquitin-protein E3 ligase complex, which includes at least CUL-3. KLHL12 is a substrate-specific adapter for the complex, which negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of Dvl-3. KLHL12 contains six Kelch repeats and one BTB (POZ) domain, which is required for interaction with CUL-3. KLHL12 has highest expression in testis, with lower levels found in the submandibular salivary gland. The gene that encodes KLHL12 maps to human chromosome 1q32.1 Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division补体C3IP1抗体: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. Subunit: Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A补体C3IP1抗体 Interacts with DRD4, KLHL12 and SEC31A. Subcellular Location: Cytoplasmic vesicle, COPII-coated vesicle. Tissue Specificity: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. Similarity: Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. Database links: Entrez Gene: 768068 Cow Entrez Gene: 59349 Human Entrez Gene: 240756 Mouse Entrez Gene: 266772 Rat Entrez Gene: 431860 Xenopus laevis Entrez Gene: 492362 Zebrafish Omim: 614522 Human SwissProt: E1B932 Cow SwissProt: Q53G59 Human SwissProt: Q8BZM0 Mouse SwissProt: Q8R2H4 Rat SwissProt: Q6NRH0 Xenopus laevis SwissProt: Q5U374 Zebrafish Unigene: 706793 Human Unigene: 478061 Mouse Unigene: 87398 Mouse Unigene: 15513 Rat Unigene: 32296 Xenopus laevis Unigene: 81655 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
补体C3IP1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid