AP2关联激酶1抗体
规格：1mg/1ml
英文名： AAK1
别名： AAK 1; Adaptor associated kinase 1; Aak1; AAK1_HUMAN; Adaptor-associated kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; AP2 associated kinase 1;AP2 associated protein kinase 1; DKFZp686F03
分子量： 104kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AAK1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
AP2关联激酶1抗体产品介绍：background: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] Function: Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects AP2关联激酶1抗体of clathrin-mediated endocytosis. Subunit: Interacts with alpha-adaptin, AP-2, clathrin, NUMB andEPS15 isoform 2. Interacts with membrane-bound activated NOTCH1 butnot with the inactive full-length form of NOTCH1. Preferentiallyinteracts with monoubiquitinated activated NOTCH1 compared to thenon-ubiquitinated form. Subcellular Location: Cell membrane; Peripheral membrane protein(By similarity). Membrane, clathrin-coated pit (By similarity).Note=Active when found in clathrin-coated pits at the plasmamembrane. In neuronal cells, enriched at presynaptic terminals.AP2关联激酶1抗体 Innon-neuronal cells, enriched at leading edge of migrating cells (Bysimilarity). Tissue Specificity: Detected in brain, heart and liver. Isoform 1is the predominant isoform in brain. Post-translational modifications: Autophosphorylated (By similarity). Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. Gene ID: 22848 Database links: Entrez Gene: 22848 Human Entrez Gene: 269774 Mouse Entrez Gene: 500244 Rat SwissProt: Q2M2I8 Human SwissProt: Q3UHJ0 Mouse SwissProt: P0C1X8 Rat Unigene: 468878 Human Unigene: 221038 Mouse Unigene: 203307 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AP2关联激酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 激酶和磷酸酶 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid