血管抑制蛋白1抗体
规格：1mg/1ml
英文名： VASH1
别名： Vasohibin 1; KIAA1036; VASH; VASH; VASH1; VASH1_HUMAN; Vasohibin1; Vasohibin-1.
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VASH1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：分泌型蛋白
血管抑制蛋白1抗体产品介绍：background: VASH1 is a angiogenesis inhibitor. It inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. It does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis and acts in an autocrine manner. VASH1 also inhibits artery neointimal formation and macrophage infiltration and exhibits heparin-binding activity. There are two named isoforms. Function: Angiogenesis inhibitor. Inhibits migration,proliferation and network formation by endothelial cells as well asangiogenesis.血管抑制蛋白1抗体 This inhibitory effect is selective to endothelialcells as it does not affect the migration of smooth muscle cells orfibroblasts. Does not affect the proliferation of cancer cells invitro, but inhibits tumor growth and tumor angiogenesis. Acts in anautocrine manner. Inhibits artery neointimal formation andmacrophage infiltration. Exhibits heparin-binding activity. Subcellular Location: Secreted. Tissue Specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. Post-translational modifications: 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa)may血管抑制蛋白1抗体 be processed by proteolytic cleavage. The largest form (42 kDa)seems to be secreted and the other major form (63 kDa) seems toaccumulate within the cells or pericellular milieu. Polypeptideconsisting of Met-77 to Arg-318 may correspond to the 27 kDa formand that consisting of Met-77 to Val-365 may correspond to the 36kDa form. Similarity: Belongs to the vasohibin family. Gene ID: 22846 Database links: Entrez Gene: 22846 Human Entrez Gene: 238328 Mouse Entrez Gene: 503052 Rat Omim: 609011 Human SwissProt: Q7L8A9 Human SwissProt: Q8C1W1 Mouse Unigene: 525479 Human Unigene: 216101 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. VASH1是一个内皮组织衍生的可被血管内皮生长因子诱导的分泌性蛋白质,它是目前为止发现的**以负反馈为作用机制调节血管新生的因子。它的发现证实在血管新生的过程中也存在经典的自身调节控制机制—负反馈调节机制的存在。
血管抑制蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid