FAM123A蛋白抗体
规格：1mg/1ml
英文名： FAM123A
别名： AMER2_HUMAN; Fam123a; Family with sequence similarity 123, member A; Family with sequence similarity 123A; FLJ25477; Protein FAM123A.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAM123A
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：
产品介绍：background: The FAM123A (family with sequence similarity 123A) gene encodes for a 671 amino acid protein. There are two isoforms of FAM123A蛋白抗体FAM123A that exist as a result of alternative splicing events. The gene encoding FAM123A is located on chromosome 13, which comprises nearly 4% of human DNA and contains about 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1,FAM123A蛋白抗体 which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Function: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating toFAM123A蛋白抗体 the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Subunit: Interacts with APC. Subcellular Location: Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. Similarity: Belongs to the FAM123 family. Gene ID: 219287 Database links: Entrez Gene: 219287 Human SwissProt: Q8N7J2 Human Unigene: 528335 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FAM123A蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid