EXOSC6蛋白抗体
规格：1mg/1ml
英文名： EXOSC6
别名： EAP4; Exosome component 6; hMtr3; hMtr3p; EXOS6_HUMAN; homolog of yeast mRNA transport regulator 3; Mtr3 (mRNA transport regulator 3)-homolog; MTR3; Mtr3p; p11.
分子量： 28kDa
存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EXOSC6
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
EXOSC6蛋白抗体产品介绍：background: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008] Function: EXOSC6 constitutes one of the subunits of the multisubunit particle EXOSC6蛋白抗体called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known; however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. Subunit: Component of the RNA exosome complex. Specifically part of the catalyticallyEXOSC6蛋白抗体 inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Subcellular Location: Cytoplasm (Probable). Nucleus, nucleolus (Probable). Nucleus (Probable). Similarity: Belongs to the RNase PH family. Gene ID: 118460 Database links: Entrez Gene: 118460 Human Entrez Gene: 72544 Mouse Entrez Gene: 326786 Zebrafish Omim: 606490 Human SwissProt: Q5RKV6 Human Unigene: 660633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
EXOSC6蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转运蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid