ETV3蛋白抗体
规格：1mg/1ml
英文名： ETV3
别名： AI414410; bA110J1.4; ETS domain transcriptional repressor PE1; ETS family transcriptional repressor; ETS translocation variant 3; ets variant 3; ets variant gene 3; ets variant gene 3, ETS family tran
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ETV3
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
ETV3蛋白抗体产品介绍：background: ETV3 belongs to the ETS family of transcription factors and functions as a transcriptional repressor. ETS family members share a highly conserved DNA binding domain and play a role in growth factor pathways regulating proliferation and differentiation. PE-1 is ubiquitously expressed and localizes to the nucleus. Its expression can be induced by IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10 downstream anti-inflammatory effects. During terminal cell differentiation, PE-1 plays a role in growth ETV3蛋白抗体arrest by specifically repressing the target genes that are involved in Ras-dependent proliferation. The contributions of PE-1 to these anti-proliferative effects are heavily dependent on its interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing events. Function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved inETV3蛋白抗体 Ras-dependent proliferation. Represses MMP1 promoter activity. Subcellular Location: Nucleus. Similarity: Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Gene ID: 2117 Database links: Entrez Gene: 2117 Human Entrez Gene: 27049 Mouse Entrez Gene: 295297 Rat Omim: 164873 Human SwissProt: P41162 Human SwissProt: Q8R4Z4 Mouse Unigene: 105636 Human Unigene: 219460 MouseUnigene: 225088 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ETV3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid