ESF1蛋白抗体
规格：1mg/1ml
英文名： ESF1
别名： ABT1-associated protein; ABTAP; bA526K24.1; C20orf6; Esf1; ESF1 homolog; ESF1_HUMAN; FLJ20368; HDCMC28P; OTTHUMP00000030301.
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ESF1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞核
ESF1蛋白抗体产品介绍：background: In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multi-protein complex near the transcription start site by interacting with core promotor elements such as the TATA box, generally located 25-30 base pairs upstream of the transcriptionESF1蛋白抗体 start site. ABT1 (activator of basal transcription 1) is a nuclear protein that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. ABT1 forms a complex with ESF1, also designated ABT1-associated protein (ABTAP), which disrupts ABT1 interaction with TBP and suppresses ABT1-induced activation of Pol II-directed transcription. The ABT1/ESF1 ESF1蛋白抗体complex colocalizes in the nucleolus and nucleoplasm. Function: May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1. Subcellular Location: Nucleus； nucleolus. Nucleus； nucleoplasm. Similarity: Belongs to the ESF1 family. Gene ID: 51575 Database links: Entrez Gene: 51575 Human SwissProt: Q9H501 Human Unigene: 369284 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ESF1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转运蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid