腺苷A2A受体抗体
规格：1mg/1ml
英文名： Adenosine Receptor A2a
别名： Adenosine Receptor A2a; Adenosine A2A-R; A2AR; A2A adenosine receptor; A2AAR; A2aR; ADENO; Adenosine A2 receptor; Adenosine A2a receptor; Adenosine receptor subtype A2a; Adenosine Receptor A2a; ADORA
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human A2AR
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
腺苷A2A受体抗体产品介绍：background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders.腺苷A2A受体抗体 Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013] Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Subunit: Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. 腺苷A2A受体抗体Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 135 Database links: Entrez Gene: 135 Human Entrez Gene: 11540 Mouse Entrez Gene: 25369 Rat Omim: 102776 Human SwissProt: P11617 Dog SwissProt: P29274 Human SwissProt: Q60613 Mouse SwissProt: P30543 Rat Unigene: 197029 Human Unigene: 333734 Mouse Unigene: 11180 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 腺苷A2A受体参与神经递质运输、吞噬、细胞凋亡、炎症应答、细胞防御应答、信号转导。 腺苷是腺嘌呤核苷酸代谢的中间产物。是一种保护正常组织免于炎症损伤的关键的、多余的负调节**细胞。由cAMP 生物合成。
腺苷A2A受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid