eIF4H蛋白抗体
规格：1mg/1ml
英文名： eIF4H
别名： AU018978; D5Ertd355e; E430026L18Rik; Ef4h; eIF 4H; eIF-4H; EIF4H; eukaryotic translation initiation factor 4H; IF4H_HUMAN; KIAA0038; WBSCR1; Williams Beuren syndrome chromosomal region 1 protein homol
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human eIF4H
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Orangutan
细胞定位：细胞浆
eIF4H蛋白抗体产品介绍：background: This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008] Function: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. Subcellular Location: Cytoplasm; perinuclear region. Tissue Specificity: The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscleeIF4H蛋白抗体. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney. DISEASE: Note=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copyeIF4H蛋白抗体 repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. Similarity: Contains 1 RRM (RNA recognition motif) domain. Gene ID: 7458 Database links: Entrez Gene: 7458 Human Entrez Gene: 517409 Cow Entrez Gene: 22384 Mouse Entrez Gene: 288599 Rat Omim: 603431 Human SwissProt: Q1JPH6 Cow SwissProt: Q15056 Human SwissProt: Q9WUK2 Mouse SwissProt: Q5RBR8 Orangutan SwissProt: Q5XI72 Rat Unigene: 520943 Human Unigene: 27955 Mouse Unigene: 79423 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
eIF4H蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 发育生物学 神经生物学 转运蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid