eIF3β蛋白抗体
规格：1mg/1ml
英文名： EIF3S2
别名： eIF-3-beta; eIF3 beta; eIF3 p36; eIF3-beta; eIF3-p36; eIF3i; EIF3I_HUMAN; EIF3S2; EIF3S2, formerly; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3 sub
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EIF3S2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆
eIF3β蛋白抗体产品介绍：background: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, eIF3 epsilon, eIF3 omega, eIF3 eta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. OverexpressioneIF3β蛋白抗体 of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis. Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S eIF3β蛋白抗体ribosomal subunits prior to initiation. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated by TGF-beta type II receptor. Similarity: Belongs to the eIF-3 subunit I family. Contains 5 WD repeats. Gene ID: 8668 Database links: Entrez Gene: 8668 Human Entrez Gene: 419653 Chicken Entrez Gene: 521747 Cow Entrez Gene: 54709 Mouse Entrez Gene: 100008959 Rabbit Entrez Gene: 682390 Rat Entrez Gene: 447488 Xenopus laevis Entrez Gene: 548498 Xenopus tropicalis Omim: 603911 Human SwissProt: Q5E966 Cow SwissProt: Q13347 Human SwissProt: Q9QZD9 Mouse SwissProt: Q5IH81 Rabbit SwissProt: B0BNA7 Rat SwissProt: Q66J51 Xenopus laevis SwissProt: Q5EBE8 Xenopus tropicalis Unigene: 530096 Human Unigene: 250874 Mouse Unigene: 162577 Rat Unigene: 77336 Xenopus laevis Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
eIF3β蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转运蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid