EDEM1蛋白抗体
规格：1mg/1ml
英文名： EDEM1
别名： EDEM 1; EDEM1_HUMAN; EDEM; Endoplasmic reticulum degradation enhancing alpha mannosidase like protein; ER degradation enhancer, mannosidase alpha like 1; ER degradation enhancing alpha mannosidase lik
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：
EDEM1蛋白抗体产品介绍：background: Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein isEDEM1蛋白抗体 a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p. Function: EDEM1 is directly involved in ER associated degradation (ERAD), and targets misfolded glycoproteins for degradation in an N glycan EDEM1蛋白抗体dependent manner. It lacks mannosidase activity. EDEM1 belongs to the glycosyl hydrolase 47 family. Subunit: Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L. Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the glycosyl hydrolase 47 family. Gene ID: 9695 Database links: Entrez Gene: 9695 Human Entrez Gene: 192193 Mouse SwissProt: Q92611 Human SwissProt: Q925U4 Mouse Important Note: This EDEM1蛋白抗体product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid