ECM29蛋白抗体
规格：1mg/1ml
英文名： ECM29
别名： ECM29 homolog, proteasome accessory protein; FLJ22036; ECM29_HUMAN; KIAA0368; KIAA1962; Proteasome associated protein ECM29 homolog; RP11-386D8.2.
分子量： 204kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ECM29
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
ECM29蛋白抗体产品介绍：background: ECM29 is a 1,845 amino acid protein containing twenty-seven HEAT repeats. Localizing primarily to endoplasmic reticulum, ECM29 acts as an adapter or scaffolding protein, binding to the 26S proteasome, motor proteins, and other compartment specific proteins. The N-terminus of ECM29 binds endocytic proteins, including rabaptin, Rab11-FIP4, and VPS11, while the ECM29蛋白抗体C-terminus binds myosins and kinesins. ECM29 may also play a role in endoplasmic reticulum (ER)-associated protein degradation (ERAD) in addition to other enhanced proteolysis. Function: ECM29 appears to be one of three proteins which associate significantly with proteasomes. ECM29 has been shown to enhance the stability of the proteasome. ECM29 deletion has been shown to produce 26S proteasomes which dissociated in the absence of ATP. It was thus suggested that ECM29 tethers the regulatory complex to the proteasome. Subcellular Location: EndoplasmicECM29蛋白抗体 reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm ?cytoskeleton ?centrosome. Nucleus. Similarity: Contains 27 HEAT repeats. Gene ID: 23392 Database links: Entrez Gene: 23392 Human Entrez Gene: 230249 Mouse SwissProt: Q5VYK3 Human SwissProt: Q6PDI5 Mouse Unigene: 368255 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ECM29蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid