双特异性磷酸酶抗体13抗体
规格：1mg/1ml
英文名： DUSP13
别名： BEDP; Branching enzyme interacting dual specificity protein phosphatase; Dual specificity phosphatase 13; Dual specificity phosphatase SKRP4; DUSP13A; FLJ32450; DS13A_HUMAN; MDSP; Muscle restricted du
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DUSP13
交叉反应：Human, Mouse, Rat,
细胞定位：
双特异性磷酸酶抗体13抗体产品介绍：background: Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the双特异性磷酸酶抗体13抗体 downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008] Function: DUSP13 may be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. It exhibits intrinsic phosphatase 双特异性磷酸酶抗体13抗体activity towards both phospho-seryl/threonyl and -tyrosyl residues of myelin basic protein. Subunit: Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1. Subcellular Location: Cytoplasm. Tissue Specificity: Skeletal muscle specific. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 51207 Database links: Entrez Gene: 51207 Human Entrez Gene: 27389 Mouse Entrez Gene: 361002 Rat Omim: 613191 Human SwissProt: Q9UII6 Human SwissProt: Q9QYJ7 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双特异性磷酸酶抗体13抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid